Rams vs 49ers Score: Thrilling Rivalry Delivers Unforgettable 2025 Results -

If you’re a football fan who loves drama, heartbreak, and clutch moments, the Rams vs 49ers score from the 2025 NFL season was made for you. This rivalry is one of the most intense in the entire NFC. Every single time these two teams step on the field, something unforgettable happens. The 2025 season gave us not one but two absolutely wild matchups between the Los Angeles Rams and the San Francisco 49ers. Both games told completely different stories. One was a miracle survival act by a battered 49ers squad. The other was a dominant demolition by a Rams team firing on all cylinders. If you missed either game, you’re in for a treat. This article breaks down both matchups in full — the scores, the stars, the big moments, and what it all means for the NFC West race.

Table of Contents

Week 5: The Rams vs 49ers Score That Shocked Everyone

49ers Win 26-23 in Overtime — Without Almost Everyone

Let’s be real. When you heard that the San Francisco 49ers were heading into SoFi Stadium on a short week, without Brock Purdy, without Nick Bosa, without George Kittle, and without their top three wide receivers — you probably wrote them off. I know I did. The Rams were surging. They were at home. The 49ers were essentially running out their backup roster.

But that’s why they actually play the games.

The final Rams vs 49ers score from Week 5 was 49ers 26, Rams 23 in overtime. It was one of the most improbable results of the entire 2025 NFL season. Mac Jones, filling in at quarterback, threw for 342 yards and two touchdowns — all while playing through a leg injury. He was gritty, composed, and absolutely deserved the win. The 49ers scored on their first two drives and built a 20-7 lead late in the game.

But the Rams clawed back. Matthew Stafford is too good to stay quiet for long. Los Angeles tightened things up and forced overtime. Then came the moment that defined this game. With the Rams facing fourth-and-1 at the San Francisco 11-yard line in overtime, coach Sean McVay called a running play. Kyren Williams got the ball. He was inches from scoring the go-ahead touchdown. Then rookie defensive lineman Alfred Collins punched the ball out and fell on it.

“It was a must-have-it play, because if I didn’t do that, they would have scored,” CBSSports.com Collins said. The 49ers survived. Eddy Piñeiro had already hit the go-ahead field goal moments earlier to set the stage.

McVay was devastated after the call. “I’m pretty sick right now,” CBSSports.com he admitted. It was a hard lesson in a rivalry that never forgives mistakes.

Key Stats from Week 5

The Rams vs 49ers score in Week 5 doesn’t capture just how wild the game was. Here’s a quick look at what stood out:

Mac Jones: 342 passing yards, 2 TDs, playing through a leg injury
Christian McCaffrey: 139 total yards, the engine of the 49ers offense
Eddy Piñeiro: 4 field goals, including the overtime winner from 41 yards
Alfred Collins: Forced fumble and recovery that sealed the victory
Kyren Williams: Big day for LA, but the fumble at the goal line defined his night

The 49ers improved to 4-1 on the season with that win. It was a massive statement game. Even short-handed, this team found a way to win.

Week 10: Rams vs 49ers Score Gets Flipped — And It Wasn’t Close

Rams Win 42-26 in a Statement Blowout

Fast forward to Week 10. The Rams hadn’t forgotten what happened in overtime at SoFi Stadium. Matthew Stafford and Sean McVay wanted revenge. The 49ers, meanwhile, were still banged up. Purdy remained inactive for the sixth straight game with a toe injury. Nick Bosa was out for the season. Fred Warner was done. First-round rookie Mykel Williams had just suffered a season-ending knee injury.

The Rams vs 49ers score from Week 10 told you everything: Rams 42, 49ers 26.

It wasn’t that close, either. The Rams scored touchdowns on their first three possessions for the first time in five years, jumping out to a 21-0 lead early in the second quarter. CBSSports.com By the time the 49ers could blink, they were already in a massive hole.

This was Stafford at his absolute best. He finished 24 for 36 for 280 yards and became the ninth player in NFL history with at least 400 career touchdown passes. CBSSports.com He connected with Davante Adams, Puka Nacua, Davis Allen, and Colby Parkinson on scoring plays. It was a masterclass.

Stafford also set an NFL record with his third straight game posting at least four touchdown passes and zero interceptions. CBSSports.com That kind of consistency is historically rare. Davante Adams — who played with Aaron Rodgers during three MVP seasons — didn’t hold back when assessing Stafford’s play. “It’s looked like MVP play to me all year, to be honest,” CBSSports.com Adams said.

Kyren Williams Bounced Back in a Big Way

Williams had a lot to prove after that gut-punch fumble in Week 5. He delivered. Williams added two touchdown runs as the Rams scored on six of their first eight drives of the game. CBSSports.com It was a dominant performance from start to finish. The 49ers never really threatened to make it a contest in the second half.

Mac Jones connected for a late score to make the Rams vs 49ers score look a little more respectable, but the outcome was never in doubt. The Rams had made their point loud and clear.

Stafford on Reaching 400 TDs

Stafford’s milestone moment added extra meaning to this particular Rams vs 49ers score. Reaching 400 career touchdown passes puts him in elite company. “It’s awesome. It’s super cool,” CBSSports.com Stafford said. “I’m just such a huge fan of the NFL. I have so much respect for the guys that came before me.” CBSSports.com That kind of humility from a player performing at that level is something fans genuinely appreciate.

What These Two Rams vs 49ers Scores Mean for the NFC West

The 2025 NFC West has been a battle all year. After Week 10, both the Rams and the 49ers sat at 7-3, tied for second place in the division behind the Seattle Seahawks (8-2 at the time). The fact that each team split the season series means the tiebreaker situation stayed tight heading into the second half of the season.

Here’s the bigger picture you need to understand:

The 49ers showed incredible resilience in Week 5. They proved that their culture and coaching staff can compete even when the injury report looks like a hospital waiting list. That win could prove massive in playoff seeding. But the Week 10 Rams vs 49ers score showed that when Los Angeles gets healthy and hot, they’re a genuine Super Bowl contender.

Stafford’s form has been historic. The Rams defense has been solid. McVay seems to have the offense operating at peak efficiency. And for the 49ers, the hope is that Purdy returns healthy and the defense can cobble together enough healthy bodies to stay competitive.

The History Behind This Rivalry

The Rams vs 49ers rivalry is one of the fiercest in the NFC. These two franchises share a division and a competitive DNA that makes every game feel like the playoffs. Since the Rams relocated to Los Angeles, the intensity has only grown. Both teams have made deep postseason runs in recent years, and both have faced each other in high-stakes situations multiple times.

The 2021 NFC Championship Game — where the Rams knocked out the 49ers at SoFi Stadium — remains one of the defining moments of this rivalry. From Cooper Kupp’s heroics to that final drive, the game had everything. It set the stage for years of bad blood and bigger battles.

When you look at the Rams vs 49ers score from Week 5 of 2025, it fits perfectly into that narrative. The 49ers, desperate and short-handed, found a way. Then the Rams answered in Week 10 with an emphatic statement. That’s what good rivalries do. They always find a way to keep the score close in meaning, even when the scoreboard isn’t.

Injuries That Shaped Both Games

You can’t talk about the Rams vs 49ers score from 2025 without talking about injuries. The 49ers were decimated all season long. Here’s a breakdown of who was missing:

49ers key absences:

Brock Purdy (toe injury, missed six straight games)
Nick Bosa (season-ending injury)
Fred Warner (season-ending injury)
George Kittle (Week 5)
Mykel Williams (season-ending knee injury after Week 9)
Top three wide receivers (Week 5)

Rams injury notes:

Rob Havenstein and Tyler Higbee were inactive for Week 5
Davante Adams left Week 10 with an oblique injury, though he was hopeful about missing time

The injury context matters a lot when you analyze both scores. The 49ers’ win in Week 5 deserves even more credit given what they were dealing with. And the Rams’ Week 10 blowout came against a genuinely undermanned opponent. Both results still count the same in the standings, of course. But history will remember the context.

Coaching Decisions That Defined the Rams vs 49ers Score

In Week 5, the biggest coaching story was McVay’s fourth-down call in overtime. He chose a run. It didn’t work. He owned it immediately. That kind of accountability is what makes McVay one of the better coaches in the game even when he makes mistakes.

In Week 10, McVay had his team playing at a historically high level. The early 21-0 lead removed all doubt early. The play-calling was crisp. The game planning was excellent. “He’s just been in total command,” CBSSports.com McVay said about Stafford. The two have a special connection that shows up clearly when the offense is rolling like this.

Kyle Shanahan, for his part, managed the Week 5 game brilliantly with almost nothing to work with. His ability to scheme around injuries and keep his team competitive is one of the reasons San Francisco remains a destination franchise despite their injury luck in 2025.

Final Takeaways: What You Need to Remember About the Rams vs 49ers Score in 2025

The Rams vs 49ers score from the 2025 NFL season delivered exactly what this rivalry always promises — drama, big plays, and results that matter deeply for the NFC West standings.

Here’s what you should walk away knowing:

The 49ers won in Week 5, 26-23 in overtime, with a makeshift lineup that refused to quit. The Rams dominated in Week 10, 42-26, with Stafford setting records and the offense looking unstoppable. Both games influenced the NFC West race. Both teams remained in playoff contention heading into the second half of the year. And Matthew Stafford joined a very exclusive club with 400 career touchdown passes.

This rivalry never disappoints. Whether you’re a Rams fan celebrating the Week 10 blowout or a 49ers fan clinging to that miracle overtime win, there’s something here for everyone. The next chapter of this rivalry is always worth watching.

What did you think of these matchups? Were you surprised by the Week 5 result, or did you see Stafford’s Week 10 breakout coming? Drop your thoughts below and let the debate begin.

FAQs: Rams vs 49ers Score 2025

Q1: What was the Rams vs 49ers score in Week 5 of the 2025 NFL season? The final score was 49ers 26, Rams 23 in overtime. San Francisco pulled off an improbable road win despite missing most of their starters.

Q2: What was the Rams vs 49ers score in Week 10 of 2025? The Rams won decisively, 42-26, at Levi’s Stadium. It was a dominant performance led by Matthew Stafford.

Q3: Who was the quarterback for the 49ers in the Week 5 win? Mac Jones started in place of injured Brock Purdy. He threw for 342 yards and two touchdowns while playing through a leg injury.

Q4: How many touchdown passes did Stafford throw in Week 10? Stafford threw four touchdown passes in the Week 10 win, continuing his historic stretch of at least four TDs and zero interceptions in three straight games.

Q5: Did Brock Purdy play in either Rams vs 49ers game in 2025? No. Purdy was inactive for both matchups due to a toe injury. He missed six consecutive games during that stretch of the season.

Q6: What milestone did Stafford reach in the Week 10 Rams vs 49ers game? Stafford became the ninth player in NFL history to throw 400 career touchdown passes during the Week 10 victory.

Q7: Who made the game-saving play in the Week 5 overtime game? Rookie defensive lineman Alfred Collins forced and recovered a fumble from Kyren Williams at the goal line with just over a minute left in overtime, sealing the 49ers’ win.

Q8: What was the NFC West standings impact after both Rams vs 49ers games? Both teams finished with identical records after splitting the season series, keeping the NFC West race tight behind the Seattle Seahawks.

Q9: Who led the 49ers in rushing in the Week 5 overtime win? Christian McCaffrey was the offensive engine, finishing with 139 total yards in the victory.

Q10: Which Rams receiver had the most impact in the Week 10 blowout? Davante Adams was a major target for Stafford, catching a touchdown before leaving with an oblique injury in the second half.

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Author: Johan Harwen

E-mail: johanharwen314@gmail.com

Bio: Johan Harwen is a passionate tourist who has explored countless destinations across the globe. With an eye for hidden gems and local cultures, he turns every journey into an unforgettable story worth sharing.